Diabetes and tricyclic treatment of depression

Data from the Diabetes Prevention Program published in the journal Diabetes Care in 2008 showed that individuals at risk of diabetes have a further increased risk when treated for depression. The actual depression score had no association with diabetes, so the result was related specifically to treatment. The risk was greater when patients were treated with both tricyclics and selective serotonin reuptake inhibitors (SSRI), even more than the risk with tricyclics alone. Read more about why patients with impaired glucose tolerance should avoid tricyclics.