Fibrates, also known as fibric acid derivatives, are drugs prescribed to prevent heart disease by lowering triglyceride levels. Hypertriglyceridemia has been linked to atherosclerosis and heart disease, specifically the risk for coronary artery disease. Fibrates are also used to prevent pancreatitis caused by very high triglyceride level.
Fibrates in the United States include Lopid (gemfibrozil) and Tricor (fenofibrate). Gemfibrozil has been shown to decrease the risk of heart attack in individuals with coronary artery disease and low HDL levels. However, fibrates do not lower LDL on their own. Most patients tolerate fibric acid derivatives well, but like any other pharmaceutical treatment they can have side effects.
Read more about fibrates.